A 34-year-old woman had normal results of non-invasive prenatal screening. Ultrasonography at 17 gestational weeks revealed fetal kidney dysplasia. Doctors recommended amniocentesis for chromosomal abnormality detections. The test results showed a 1.48 Mb deletion in chromosome 17 of the amniotic fluid sample. According to authoritative database, the deletion is a clear pathogenic mutation which can lead to renal cysts and diabetes syndrome. The doctor induced labor according to the opinions of the couple, avoided the birth of the child.